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Molfinity

NIC-12 - CAS 2409826-23-7

NIC-12 - CAS 2409826-23-7

MF-0121035-01

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Product Details

  • Bioactivity

    NIC-12, a potent NLRP3 inhibitor, selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model and inhibits NLRP3 inflammasome activation in mouse macrophages [1].

  • Target

    NOD-like Receptor (NLR)

  • Related Pathways

    Immunology/Inflammation

  • CAS Number

    2409826-23-7

  • Molecular Formula

    C22H28ClN5O2S

  • Molecular Weight

    462.01

  • SMILES

    C(C)(C)C=1N2C3=C(C=C2C(=O)N(CC(N[C@H]4CN(CC5CC5)CCC4)=O)N1)SC(Cl)=C3

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound