Nicotinamide Hydrochloride - CAS 25334-23-0

Nicotinamide Hydrochloride, a form of vitamin B3 (niacin), inhibits sirtuin 2 (SIRT2) activity in vitro with an EC50 of 2 μM, reducing melanoma cell number by up to 90% and increasing cellular NAD+, ATP, and ROS levels. It also inhibits tumor growth in vivo and improves survival in melanoma-bearing mice, making it useful for skin cancer research, including melanoma.

Others, Endogenous Metabolite, HBV, Sirtuin

Others, DNA Damage/DNA Repair, Chromatin/Epigenetic, Metabolism, Microbiology/Virology

25311

C6H7ClN2O

158.59

Cl.O=C(N)C=1C=NC=CC1

-20°C

Ice Packs

Small Compound