NiCur - CAS 2674753-39-8

NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM. NiCur blocks CBP HAT activity, downregulates p53 activation and inhibits apoptosis, while promoting methylation of Lysine 27 on histone H3, inhibiting Caspase 3 activity and PARP cleavage.

Apoptosis, PARP, Caspase, Epigenetic Reader Domain, Histone Acetyltransferase

Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

2674706

0.9922

C22H16N2O

324.38

C(=C\1/C(=O)\C(=C\C2=CC(C#N)=CC=C2)\CCC1)\C3=CC(C#N)=CC=C3

-20°C

Ice Packs

Small Compound