Nimbolide - CAS 25990-37-8

Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L) .

CDK, Wnt/beta-catenin, Apoptosis, NF-κB

NF-κB, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Stem Cells, Apoptosis

25945

0.994

C27H30O7

466.52

C[C@]12[C@]3([C@]([C@@]4([C@](C)([C@@H]1CC(OC)=O)C=5[C@](O4)(C[C@H](C5C)C=6C=COC6)[H])[H])(OC(=O)[C@]3(C)C=CC2=O)[H])[H]

-20°C

Ice Packs

Natural Product