Nintedanib - CAS 656247-17-5

Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM) . Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis.

PDGFR, FLT, VEGFR, FGFR, Src

Tyrosine Kinase/Adaptors, Angiogenesis

656247-17-5

0.9992

C31H33N5O4

539.62

COC(c1cc2c(/C(C(N2)=O)=C(c3ccccc3)/Nc4ccc(N(C(CN5CCN(CC5)C)=O)C)cc4)cc1)=O

-20°C

Ice Packs

Small Compound