NIR-BG2 - CAS 3036456-18-2

NIR-BG2 is a near-infrared fluorescent probe that targets senescence-associated β-galactosidase (SA-β-Gal) . Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis, releasing an electrophilic methylquinone that covalently binds to surrounding proteins for in situ labeling, enhancing the fluorescence signal 16-fold at 709 nm. NIR-BG2 holds potential for in vivo imaging studies of cellular senescence.

Others, glycosidase

Others, Metabolism

3036456-18-2

C42H46F2NO8

730.81

C(CC)[N+]=1C=2C(C(C)(C)C1/C=C/C3=C4C(=CC=5C(O4)=CC(OCC6=CC=C(O[C@@H]7O[C@H](CO)[C@H](O)[C@H](O)[C@H]7O)C=C6)=C(C(F)F)C5)CCC3)=CC=CC2

-20°C

Ice Packs

Natural Product