Niraparib hydrochloride - CAS 1038915-64-8

Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.

PARP, Apoptosis

DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic

1038843

0.9985

C19H21ClN4O

356.85

C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl

-20°C

Ice Packs

Small Compound