Niraparib tosylate monohyrate - CAS 1613220-15-7

Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.

Apoptosis, PARP

Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic

1613198

0.9999

C26H30N4O5S

510.61

CC1=CC=C(S(=O)(O)=O)C=C1.O=C(N)C(C2=N3)=CC=CC2=CN3C(C=C4)=CC=C4[C@@H]5CCCNC5.O

-20°C

Ice Packs

Small Compound