Nitric oxide production-IN-2 - CAS 1019984-44-1

TLR4/JNK/NF-κB-IN-1 (Racemic-11k) is an inhibitor of TLR4, JNK, and NF-κB. It suppresses NO production in LPS-stimulated RAW264.7 cells with an IC50 of 23.2 μM. By inhibiting TLR4 expression and reducing JNK phosphorylation, TLR4/JNK/NF-κB-IN-1 prevents NF-κB activation. This leads to a decrease in the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and the production of inflammatory mediators such as NO, PGE2, and TNF-α, thereby exhibiting anti-inflammatory activity. TLR4/JNK/NF-κB-IN-1 holds potential in the study of inflammatory diseases, including rheumatoid arthritis and various other inflammatory conditions.

NF-κB, JNK, TLR

MAPK, NF-κB, Immunology/Inflammation

1019939

C23H20O3

344.403

O=C1C2=CC=C(OC)C=C2C(C=3C=CC=CC3)C1C4=CC=C(OC)C=C4

-20°C

Ice Packs

Small Compound