NLCQ-1 HCl - CAS 221292-08-6

NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypoxic cytotoxin ranged between 10 and 136 microM x h, for the cell lines tested, at 30 microM input concentration. NLCQ-1 was a very potent and efficient radiosensitizer of hypoxic V79 cells, providing SER values of 2.27-2.56 at 20-80 microM concentration (measured at 10% survival level) . Preclinical results suggest a possible use of NLCQ-1 as adjuvants to radiotherapy.

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221292-08-6

C15H15Cl2N5O2

368.22

Cl.O=N(=O)C1=NC=CN1CCCNC=2C=CN=C3C=C(Cl)C=CC32

-20°C

Ice Packs

Small Compound