[Nle20] H4 peptide (16−23) - CAS 2042178-19-6

[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting strong inhibitory activity (Kd = 0.14 μM) by competing for the substrate binding site on SETD8, thereby inhibiting its methylation of histone H4. This peptide can serve as a lead compound in anticancer therapy.

2042178-19-6

C47H88N20O9

1077.33

[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CC(C)C)=O)C(C)C)=O)CCCC)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@H](CCCCN)N)=O)CCCNC(=N)N)=O

-20°C

Ice Packs

Small Compound