NLRP3/AIM2-IN-3 - CAS 1787787-60-3

NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.

NOD, Pyroptosis, NOD-like Receptor (NLR), AIM2

Immunology/Inflammation, NF-κB, Apoptosis

1787724

0.9716

C16H14N2O2

266.29

Oc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1

-20°C

Ice Packs

Small Compound