NLRP3-IN-20 - CAS 2428478-22-0

NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic properties and has shown significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis [1].

NOD-like Receptor (NLR)

Immunology/Inflammation

2428456

C22H27N3O3S

413.53

N(C(NS(=O)(=O)C1=CC=C(CN(C)C)C=C1)=O)C2=C3C(=CC4=C2CCC4)CCC3

-20°C

Ice Packs

Small Compound