NLRP3-IN-25 - CAS 2660230-90-8

NLRP3-IN-25 (compound 32), an orally available NLRP3 inhibitor, exhibits anti-inflammatory properties by attenuating renal injury in a mouse model of doxorubicin-induced glomerulonephritis and inhibiting IL-1β secretion in THP-1 cells, with an IC 50 value of 21 nM [1].

Interleukin, NOD-like Receptor (NLR)

Immunology/Inflammation

2660230-90-8

C17H19F3N4O5S

448.42

N(C1=CC(C(F)(F)F)=CC=C1C)C2=NC(C(NS(=O)(=O)N3CCCOCC3)=O)=CO2

-20°C

Ice Packs

Small Compound