NLRP3-IN-34 - CAS 1392502-55-4

NLRP3-IN-34 (Compound T10) acts as an inhibitor of the NLRP3 inflammasome. It blocks the production of reactive oxygen species (ROS) and impedes the formation of NLRP3 inflammasome-dependent IL-1β (J774A.1, IC50 of 0.48 μM), while also inhibiting pyroptosis (cell suicide) . Additionally, NLRP3-IN-34 displays anti-inflammatory activity in a C57BL/6 mouse model for DSS-induced peritonitis.

1392502-55-4

C26H22O6

430.45

O=C(OC1C=2C=3C(=O)C(=O)C4=C(OC=C4C)C3C=CC2C(C)(C)CC1)C=5C=CC=CC5O

-20°C

Ice Packs

Small Compound