Molfinity

NLRP3-IN-62 - CAS 3059965-71-5

SKU:MF-0112438-01

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Product Details

Bioactivity
NLRP3-IN-62 (Compound 1) is an inhibitor of NLRP3. It effectively inhibits pyroptosis in THP-1 cells with an IC50 of 0.7 nM and suppresses IL-β release with an IC50 of 108.5 nM.
Target
NOD-like Receptor (NLR), Pyroptosis
Related Pathways
Immunology/Inflammation, Apoptosis
CAS Number
3059889
Molecular Formula
C21H15F3N4O3
Molecular Weight
428.36
SMILES
O=C1C=C2C(=CN1)CN(C3=NC4=NC(=CC=C4O3)C5=C(O)C=C(C=C5C)C(F)(F)F)C2
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound