NLRP3-IN-69 - CAS 3027608-60-9

NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.

COX, NOD-like Receptor (NLR), NF-κB, Interleukin, NO Synthase

Immunology/Inflammation, NF-κB, Neuroscience

3027539

C25H24O7

436.454

O(C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)=O)C2=CC3=C(C=C([C@@H](C(O)=O)C)C=C3)C=C2

-20°C

Ice Packs

Small Compound