NLRP3-IN-70 - CAS 1997362-01-2

NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.

NOD-like Receptor (NLR)

Immunology/Inflammation

1997362-01-2

C23H23NO5

393.432

O=C1C(=O)C2=C(C=CC3=C2CCCC3(C)C)C=4OC=C(C(=O)N5CCOCC5)C14

-20°C

Ice Packs

Small Compound