NLRP3-IN-78 - CAS 477546-27-3

NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.

Pyroptosis, NF-κB

Apoptosis, Immunology/Inflammation, NF-κB

477516

C12H5Cl2N3O4S2

390.222

O=C(NC1=NC(=CS1)C=2C=C(Cl)SC2Cl)C=3OC(=CC3)N(=O)=O

-20°C

Ice Packs

Small Compound