NLRP3-IN-8 - CAS 2768650-56-0

NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 138.63 min) and exhibits minimal toxicity (against L02: IC50 > 100 μM) [1].

Others, NOD-like Receptor (NLR)

Others, Immunology/Inflammation

2768594

C23H20N2O6

420.41

C(=C/N(=O)=O)\C1=C(/C=C/C2=CC=C(NC(=O)C3=CC=CO3)C=C2)C=C(OC)C=C1OC

-20°C

Ice Packs

Small Compound