NLRP3-IN-81 - CAS 2922814-85-3

NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.

Interleukin, Caspase, Pyroptosis, NOD-like Receptor (NLR)

Apoptosis, Immunology/Inflammation, Proteases/Proteasome

2922726

C16H15F3N2O3S

372.36

O=S(=O)(C1=NN=C(C=C1)C=2C=CC(=CC2O)C(F)(F)F)C3CCCC3

-20°C

Ice Packs

Small Compound