NLRP3 modulator 8 - CAS 3069891-88-6

NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM) . In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1β triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.

NOD

Immunology/Inflammation, NF-κB

3069797

C20H19Cl2FN4O3

453.3

FC1=CN=C(C(C)(C)C(NCC2=CC(Cl)=C(C3C(NC(CC3)=O)=O)C(Cl)=C2)=O)N=C1

-20°C

Ice Packs

Small Compound