NMDAR antagonist 5 - CAS 3038464-68-2

NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET) . It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM) . NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM) . It has antidepressant properties and is useful for depression research.

Monoamine Transporter, Dopamine Receptor, Serotonin Transporter, iGluR

Membrane transporter/Ion channel, GPCR/G Protein, Neuroscience

3038394

C17H21N3

267.369

[C@]1(CC2=C(CC1)NN=C2)(N3CCCC3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound