NMS-P626 - CAS 942471-37-6

NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.

Trk receptor

Tyrosine Kinase/Adaptors

942428

C28H35F2N7O4S

603.68

N(C(=O)C1=C(N[C@@H](COC)C)C=C(C=C1)N2CCN(C)CC2)C=3C4=C(NN3)CCN(S(=O)(=O)C5=CC(F)=CC(F)=C5)C4

-20°C

Ice Packs

Small Compound