NMS-P953 - CAS 1403679-33-3

NMS-P953 is a JAK2 inhibitor, displaying significant tumor growth inhibition in SET-2 xenograft tumor model. NMS-P953 has a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile.

Others, JAK

Stem Cells, Tyrosine Kinase/Adaptors, Angiogenesis, Others, JAK/STAT signaling, Chromatin/Epigenetic

1403643

C16H11ClF3N5O

381.74

C(N)(=O)C1=C(NC(=C1)C2=NC(N)=NC=C2)C3=CC(C(F)(F)F)=CC=C3Cl

-20°C

Ice Packs

Small Compound