Noberastine citrate - CAS 139751-07-8

Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack central nervous system effects. After subacute (steady-state) administration of noberastine, there was increasing inhibition of weal and flare formation with higher doses of the drug. The 30 mg daily dose showed maximum antihistaminic effects.

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139751-07-8

C23H29N5O8

503.51

OC(=O)CC(O)(CC(O)=O)C(O)=O.Cc1ccc(Cn2c(NC3CCNCC3)nc3cccnc23)o1

-20°C

Ice Packs

Small Compound