Noberastine maleate - CAS 111922-05-5

Noberastine maleate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack central nervous system effects. After subacute (steady-state) administration of noberastine, there was increasing inhibition of weal and flare formation with higher doses of the drug. The 30 mg daily dose showed maximum antihistaminic effects.

Others, Histamine Receptor

Immunology/Inflammation, GPCR/G Protein, Neuroscience, Others

111922-05-5

C25H29N5O9

543.53

OC(/C=C\C(O)=O)=O.CC1=CC=C(O1)CN2C3=NC=CC=C3N=C2NC4CCNCC4.OC(/C=C\C(O)=O)=O

-20°C

Ice Packs

Small Compound