Norartocarpetin - CAS 520-30-9

Norartocarpetin is a potent tyrosinase inhibitor exhibiting significant antibrowning properties useful for food system research, with an IC50 of 0.47 μM. Furthermore, it demonstrates substantial anticancer activity specifically in lung carcinoma cells (NCI-H460), achieving an IC50 of 22 μM. The antiproliferative effects of Norartocarpetin are achieved through targeting the Ras/Raf/MAPK signaling pathway, inducing mitochondrial-mediated apoptosis, facilitating S-phase cell cycle arrest, and inhibiting cell migration and invasion in human lung carcinoma cells.

Others, MAPK, Raf, Ras, Apoptosis, Tyrosinase

MAPK, Others, GPCR/G Protein, Apoptosis, Proteases/Proteasome

481

C15H10O6

286.24

O=C1C=2C(OC(=C1)C3=C(O)C=C(O)C=C3)=CC(O)=CC2O

-20°C

Ice Packs

Natural Product