(+) -Norfenfluramine - CAS 19036-73-8

(+) -Norfenfluramine, the principal hepatic metabolite of (+) -fenfluramine, acts as a selective agonist for the 5-HT2B receptor, exhibiting a potent K i of 11.2 nM. It significantly promotes the hydrolysis of inositol phosphates and heightens intracellular Ca2+ levels. This compound is valuable in the study of primary pulmonary hypertension and valvular heart disease.

5-HT Receptor

Neuroscience, GPCR/G Protein

18955

C10H12F3N

203.2

C[C@H](N)Cc1cccc(c1)C(F)(F)F

-20°C

Ice Packs

Small Compound