Norfluoxetine-d5 HCl - CAS 1185132-92-6

Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM) . It has been found in the tissues of fish exposed to wastewater effluent.

1185034

C16H17ClF3NO

336.79

C(OC1=CC=C(C(F)(F)F)C=C1)(C(C(N)([2H])[2H])([2H])[2H])(C2=CC=CC=C2)[2H].Cl

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