NoxA1ds - CAS 1435893-78-9

Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM) . Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.

NADPH

Metabolism

1435806

C50H88N14O15

1125.33

C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)C)C(N)=O)=O)CCCCN)=O)C)=O)CCCCN)=O)=O)CC(C)C)=O)C)=O)CC(O)=O)=O)C(C)C)(=O)[C@H]1N(C([C@H](CCC(O)=O)N)=O)CCC1

-20°C

Ice Packs

Peptide