NPC-15437 dihydrochloride - CAS 141774-20-1

NPC-15437 dihydrochloride is a synthetic prototype belonging to a novel structural class of protein kinase C (PKC) inhibitors. NPC 15437 potently inhibits PKC enzymatic activity and phorbol ester binding with IC50 values around 19 μM and 23 μM, respectively, without affecting cAMP-dependent or Ca2+/calmodulin-dependent kinases at concentrations up to 300 μM, thereby demonstrating selectivity for PKC and serving as an important tool compound for dissecting PKC-mediated cellular signaling mechanisms.

PKC

Cytoskeletal Signaling, Chromatin/Epigenetic

141753

C25H52Cl2N4O2

511.62

NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl

-20°C

Ice Packs

Small Compound