NPC26 - CAS 864860-32-2

NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29) . NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.

Reactive Oxygen Species, AMPK

PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Immunology/Inflammation, Metabolism, NF-κB

864826

C19H23N3O5S2

437.533

O=C(OCC)C1=C(SC2=C1CC(NC2(C)C)(C)C)NC(=O)C=3SC(=CC3)N(=O)=O

-20°C

Ice Packs

Small Compound