NR-160 - CAS 2484895-50-1

NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM) .1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively) . NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM) . It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

Others, HDAC

DNA Damage/DNA Repair, Chromatin/Epigenetic, Others

2484844

C25H21F3N6O3

510.47

N(C(=O)C1=C(C(F)(F)F)C=CC=C1)(CC=2N(CC3=CC=CC=C3)N=NN2)CC4=CC=C(C(NO)=O)C=C4

-20°C

Ice Packs

Small Compound