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Nrf2 activator-10 - CAS 75483-04-4

Nrf2 activator-10 - CAS 75483-04-4

MF-0117416-01

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Product Details

  • Bioactivity

    Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent antioxidant response element (ARE) inducer, with an EC50 of 2.7 μM, and also acts as an Nrf2 activator. It modifies Keap1, preventing the formation of the Cul3-Keap1 ubiquitin ligase complex, thereby activating Nrf2 transcription. Nrf2 activator-10 provides cellular protection against H2O2-induced apoptosis.

  • Target

    Nrf2, Apoptosis

  • Related Pathways

    Immunology/Inflammation, Apoptosis

  • CAS Number

    75483-04-4

  • Molecular Formula

    C13H12ClNO3

  • Molecular Weight

    265.69

  • SMILES

    O=C(OCC)C=1C(=O)N(C=2C=CC=CC2C1Cl)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound