Nrf2 activator-21 - CAS 1912404-14-8

Nrf2 activator-21 is a compound that serves as an Nrf2 activator with both antioxidant and neuroprotective properties. It binds to the Keap1Kelch domain, disrupting the Keap1-Nrf2 interaction and activating antioxidant defense mechanisms. Nrf2 activator-21 decreases apoptosis of hippocampal neurons and reduces caspase-3 activity. It targets cerebral ischemia/reperfusion injury (CIRI) by activating the Nrf2 pathway. The compound improves neurological function, alleviates anxiety-like behavior induced by bilateral carotid artery occlusion (2VO) in rats, and enhances memory. Nrf2 activator-21 is applicable in studies of cerebral ischemia/reperfusion injury.

Nrf2, Caspase, Apoptosis

Proteases/Proteasome, Apoptosis, Immunology/Inflammation

1912382

C19H14O5

322.31

O=C1OC=2C=C(OC)C=CC2C=C1C(=O)C=CC3=CC=C(O)C=C3

-20°C

Ice Packs

Small Compound