Nrf2-ARE/hMAO-B/QR2 modulator 1 - CAS 3035124-25-2

Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2 (quinone reductase-2, NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.

MAO, NADPH, Reactive Oxygen Species, Monoamine Oxidase, ROS, Nrf2

NF-κB, Immunology/Inflammation, Neuroscience, Metabolism

3035097

0.985

C14H12N2O3

256.26

COC1=CC=C(/C=C/C2=NN(CC#C)C(O2)=O)C=C1

-20°C

Ice Packs

Small Compound