NRX-103094 - CAS 2763260-36-0

NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, increasing the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.

Molecular Glues, Wnt/beta-catenin

PROTAC, Cytoskeletal Signaling, Stem Cells

2763224

0.995

C20H11Cl2F3N2O4S

503.28

S(C1=C(C(NC2=CC(C(O)=O)=CC=C2)=O)C(=O)NC(C(F)(F)F)=C1)C3=C(Cl)C=CC=C3Cl

-20°C

Ice Packs

PROTAC