NRX-252114 - CAS 2763260-39-3

NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, and is able to enhance the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.

Molecular Glues, Wnt/beta-catenin

PROTAC, Stem Cells, Cytoskeletal Signaling

2763218

0.997

C22H12Cl2F3N3O2S

510.32

S(C1=C(C(=O)N2CC=3C(C2)=CC=CC3C#N)C(=O)NC(C(F)(F)F)=C1)C4=C(Cl)C=CC=C4Cl

-20°C

Ice Packs

PROTAC