NS-062 - CAS 2226257-92-5

NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.

Antibacterial, EGFR

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Microbiology/Virology

2226160

C28H30Cl2F2N6O4

623.48

N(C=1C2=C(C=C(OCCCN3CCOCC3)C(NC(=O)[C@@H]4N(C(C(Cl)F)=O)CCC4)=C2)N=CN1)C5=CC(Cl)=C(F)C=C5

-20°C

Ice Packs

Small Compound