NS 383 - CAS 309711-59-9

ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3) . Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3) . Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Sodium Channel, Others

Membrane transporter/Ion channel, Others

309711-59-9

C19H19N3O2

321.37

N(O)=C1C2=C(C3=C(C(=C2)C4=CC=CC=C4)CCN(CC)C3)NC1=O

-20°C

Ice Packs

Small Compound