NS13001 - CAS 1063331-94-1

NS13001 (N- (4-Chlorophenyl) -2- (3,5-dimethyl-1H-pyrazol-1-yl) -9-methyl-9H-purin-6-amine) is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels) . The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.

Potassium Channel

Membrane transporter/Ion channel

1063236

0.9955

C17H16ClN7

353.81

Cc1cc(C)n(n1)-c1nc(Nc2ccc(Cl)cc2)c2ncn(C)c2n1

-20°C

Ice Packs

Small Compound