NS309 - CAS 18711-16-5

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels) . It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

Potassium Channel, EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Membrane transporter/Ion channel

18690

0.9755

C8H4Cl2N2O2

231.04

ON=C1C(=O)Nc2c1ccc(Cl)c2Cl

-20°C

Ice Packs

Small Compound