NSC 109555 - CAS 15427-93-7

NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM) . Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

Others, Autophagy, Chk

Autophagy, Others, Cell Cycle/Checkpoint

15327

C21H32N10O7S2

600.67

CS(O)(=O)=O.CS(O)(=O)=O.C\C(=N/N=C(N)N)c1ccc(NC(=O)Nc2ccc(cc2)C(\C)=N\N=C(N)N)cc1

-20°C

Ice Packs

Small Compound