NSC 80467 - CAS 101982-51-8

NSC 80467 is a selective DNA-damaging agent that functions through survivin inhibition. NSC 80467 preferentially disrupts DNA synthesis, thereby inducing two hallmark DNA-damage markers, γH2AX and pKAP1. NSC 80467 enables mechanistic investigation in to DNA replication stress and apoptosis-associated signaling pathways and serves as a biochemical tool for evaluating survivin-dependent cellular processes in oncology research.

Survivin

Apoptosis

101923

0.9925

C24H22BrN3O5

512.35

O=C1C2=C(C(C3=C1N(CC(C)C)C(C)=[N+]3CC(C4=CC=C([N+]([O-])=O)C=C4)=O)=O)C=CC=C2.[Br-]

-20°C

Ice Packs

Small Compound