NSC697923 - CAS 343351-67-7

NSC-697923 (2-[ (4-methylphenyl) sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.

Apoptosis, E1/E2/E3 Enzyme

Apoptosis, Ubiquitination

343277

0.9984

C11H9NO5S

267.26

Cc1ccc(cc1)S(=O)(=O)c1ccc(o1)[N+]([O-])=O

-20°C

Ice Packs

Small Compound