NSC727447 - CAS 40106-12-5

NSC727447 is an inhibitor targeting ribonuclease H (Rnase H) in both HIV-1 and HIV-2. It exhibits minimal activity against E. coli RNase H, demonstrating significant selectivity for human Rnase H with IC50 values of 2.0 μM, 2.5 μM, 100 μM, and 10.6 μM, respectively [1].

HIV Protease, DNA/RNA Synthesis

Microbiology/Virology, Proteases/Proteasome, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

40106-12-5

C10H14N2OS

210.3

C(N)(=O)C=1C2=C(SC1N)CCCCC2

-20°C

Ice Packs

Small Compound