NSD-IN-3 - CAS 744260-15-9

NSD-IN-3 (compound 3) serves as a potent inhibitor of the nuclear receptor binding SET domain (NSD) . It effectively targets NSD2-SET and NSD3-SET, displaying IC 50 values of 0.81 μM and 0.84 μM, respectively. This compound also impedes the dimethylation of histone H3K36 and suppresses the expression of genes targeted by NSDs in non-small cell lung cancer cells. Furthermore, NSD-IN-3 promotes s-phase cell cycle arrest and induces apoptosis [1].

Histone Methyltransferase, Apoptosis

Chromatin/Epigenetic, Apoptosis

744260-15-9

C13H12BrN5O

334.17

C(COC1=CC=C(Br)C=C1)N2C=3C(N=C2)=C(N)N=CN3

-20°C

Ice Packs

Small Compound