Nsp12-IN-2 - CAS 667882-55-5

Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.

SARS-CoV, Drug Metabolite, Virus Protease

Microbiology/Virology, Metabolism

667822

C9H12N2Na3O14P3S

566.15

O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)S[C@@H]([C@H]1O)COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]

-20°C

Ice Packs

Small Compound