NU223612 - CAS 2759420-43-2

NU223612 is a potent PROTAC (PROTACs) specifically targeting and degrading indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO) ) via CRBN-mediated proteasomal degradation, demonstrating a binding affinity (Kd) of 640 nM for IDO1 and 290 nM for CRBN. Importantly, NU223612 is capable of crossing the blood-brain barrier (BBB) [1].

PROTACs, IDO, Indoleamine 2,3-Dioxygenase (IDO), Others

Others, Metabolism, PROTAC

2759375

C49H55FN6O9

890.99

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCC(=O)N4CCC(OC5=CC=C(NC([C@H](C)[C@@]6(CC[C@@H](CC6)C=7C8=C(N=CC7)C=CC(F)=C8)[H])=O)C=C5)CC4

-20°C

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PROTAC